Mast Alan E
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201-2178, USA.
Front Biosci (Schol Ed). 2011 Jun 1;3(4):1457-62. doi: 10.2741/236.
Tissue factor pathway inhibitor (TFPI) is a factor Xa dependent inhibitor of tissue factor initiated blood coagulation. In recent years several alternatively spliced forms of TFPI have been identified. These alternatively spliced forms have different C-terminal regions and have different mechanisms for association with cell surfaces. They are differentially expressed in human and mouse tissues and may have distinct physiological functions.
组织因子途径抑制物（TFPI）是一种依赖于因子Xa的组织因子启动的血液凝固抑制物。近年来，已鉴定出TFPI的几种可变剪接形式。这些可变剪接形式具有不同的C末端区域，并且与细胞表面结合的机制也不同。它们在人和小鼠组织中差异表达，可能具有不同的生理功能。
