Liu Ji-Long, Su Ren-Wei, Yang Zeng-Ming
Department of Biology, Shantou University, Shantou, China.
Front Biosci (Schol Ed). 2011 Jun 1;3(4):1511-9. doi: 10.2741/241.
Embryo implantation is a critical step in mammalian reproduction and includes apposition of the blastocyst, attachment to the uterine epithelium and decidualization of the uterine stroma. However, the key mechanism underlying embryo implantation remains to be elucidated. In recent years, high-throughput transcriptomic and proteomic approaches make it possible for studying the expression levels of thousands of genes and proteins simultaneously and thus accelerate the understanding of gene regulatory networks involved in embryo implantation. This review briefly summarizes the advance on mRNA, miRNA and protein expression profile analysis during embryo implantation in human and a variety of animal models.
胚胎着床是哺乳动物生殖过程中的关键步骤，包括囊胚定位、与子宫上皮附着以及子宫基质蜕膜化。然而，胚胎着床的关键机制仍有待阐明。近年来，高通量转录组学和蛋白质组学方法使同时研究数千个基因和蛋白质的表达水平成为可能，从而加速了对胚胎着床相关基因调控网络的理解。本文简要综述了人类及多种动物模型胚胎着床过程中mRNA、miRNA和蛋白质表达谱分析的研究进展。
