*Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea ‡Seran Eye Center, Seoul, Korea †Department of Ophthalmology, Inha University School of Medicine, Incheon, Korea.
J Glaucoma. 2013 Jan;22(1):36-43. doi: 10.1097/IJG.0b013e31821e85f3.
To assess agreement in cup-to-disc ratio (CDR) estimation between stereoscopic optic disc photography, time-domain optical coherence tomography (OCT), and Fourier-domain OCT, and to compare the discriminating ability of optic nerve head (ONH) parameters by time-domain OCT and Fourier-domain OCT for glaucoma detection.
Participants underwent stereoscopic photography, Stratus OCT (fast optic disc scan), and RTVue-100 (nerve head mapping), at the same visit. Vertical and horizontal CDRs (VCDR and HCDR) from stereoscopic photography were determined by averaging the results from 2 independent glaucoma specialists. VCDR, HCDR, disc area, cup area, rim area, and cup-to-disc area ratio were acquired from the 2 OCTs. Agreement was assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots. Area under the receiver operator characteristic curve was used to assess the ability of each parameter to detect glaucoma.
A total of 185 eyes were used in final analysis. VCDR and HCDR measurements from RTVue were highest, followed by those from Stratus OCT and stereoscopic photography. CDRs from both OCTs showed excellent agreement with those from stereophotography (ICC, 0.80 to 0.86). Agreement in ONH parameters including CDRs between the 2 OCTs was excellent (ICC, 0.86 to 0.94). There were no statistically significant differences between the ONH parameters from the 2 OCTs with respect to ability to detect glaucoma.
VCDR and HCDR measurement by time-domain and Fourier-domain OCTs exhibited excellent agreement with each other and agreed equally well with those by stereoscopic photography. The ONH parameters between the 2 OCTs performed similarly in determining glaucoma status.
评估立体眼底照相、时域光相干断层扫描（OCT）和频域 OCT 测量杯盘比（CDR）的一致性，并比较时域 OCT 和频域 OCT 的视神经头（ONH）参数对青光眼检测的鉴别能力。
参与者在同一次就诊时接受了立体摄影、Stratus OCT（快速视盘扫描）和 RTVue-100（神经头测绘）。立体摄影的垂直和水平 CDR（VCDR 和 HCDR）通过 2 位独立的青光眼专家的结果平均值确定。2 种 OCT 均获得 VCDR、HCDR、视盘面积、杯面积、边缘面积和杯盘面积比。通过组内相关系数（ICC）和 Bland-Altman 图评估一致性。受试者工作特征曲线下面积用于评估每个参数检测青光眼的能力。
共 185 只眼纳入最终分析。RTVue 的 VCDR 和 HCDR 测量值最高，其次是 Stratus OCT 和立体摄影的测量值。两种 OCT 的 CDR 与立体摄影的测量值具有极好的一致性（ICC，0.80 至 0.86）。两种 OCT 的 ONH 参数（包括 CDR）之间的一致性极好（ICC，0.86 至 0.94）。两种 OCT 的 ONH 参数在检测青光眼的能力方面没有统计学差异。
时域和频域 OCT 的 VCDR 和 HCDR 测量值彼此之间具有极好的一致性，与立体摄影的测量值也具有相同的一致性。两种 OCT 的 ONH 参数在确定青光眼状态方面表现相似。
