Department of Clinical Sciences, Lund University, University Hospital of Malmö, Sweden.
Ann Med. 2012 Aug;44(5):433-47. doi: 10.3109/07853890.2011.582511. Epub 2011 May 31.
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. In the last decades numerous markers have been considered and investigated for the prediction of CV events, but only a few of them resulted in improved global risk assessment beyond traditional risk factors when incorporated into coronary evaluation scores. Recent genetic studies have pointed out a few but consistent loci or genes which are independently associated with CV risk. The idea is fascinating that these genetic markers could lead to improved individual CV risk assessment and tailored pharmacological interventions. In this brief review we will not make a systematic review of all non-genetic and genetic markers of CV risk but we will try to make a brief overview of the most interesting ones with the aim to underline potential 'pros' and 'cons' of their implementation in clinical practice.
心血管疾病 (CVD) 是全球范围内导致死亡和残疾的主要原因。在过去几十年中，已经有许多标志物被考虑和研究用于预测心血管事件，但只有少数标志物在纳入冠状动脉评估评分后，能改善传统危险因素之外的整体风险评估。最近的遗传研究指出了少数但一致的与心血管风险相关的位点或基因。这些遗传标志物可能会提高个体心血管风险评估和针对性药物干预的想法令人着迷。在这篇简短的综述中，我们不会对所有心血管风险的非遗传和遗传标志物进行系统评价，而是尝试对最有趣的标志物进行简要概述，目的是强调其在临床实践中的潜在“优点”和“缺点”。
