Division of Clinical Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan.
Clin Transplant. 2011 Jul;25 Suppl 23:44-8. doi: 10.1111/j.1399-0012.2011.01481.x.
BK virus (BKV) nephropathy is one of the major causes of allograft dysfunction or graft loss in kidney transplant recipients. Early diagnosis and timely reduction in immunosuppressant is important for proper treatment. We report a 35-yr-old male case of cadaveric renal transplantation with BK viral related tubulointerstitial nephritis complicated by acute rejection. The diagnostic biopsy showed severe inflammatory infiltrates, tubulitis, and peritubular capillaritis. Discontinuation of mycophenolate mofetil, prednisone pulse therapy, and r-globulin was successful in relieving allograft dysfunction.
BK 病毒（BKV）肾病是导致肾移植受者移植物功能障碍或丧失的主要原因之一。早期诊断和及时减少免疫抑制剂对正确治疗非常重要。我们报告了一例 35 岁男性尸体肾移植患者，并发 BK 病毒相关的肾小管间质性肾炎和急性排斥反应。诊断性活检显示严重的炎症浸润、肾小管炎和肾小管周围毛细血管炎。停用吗替麦考酚酯、泼尼松脉冲治疗和丙种球蛋白成功缓解了移植物功能障碍。
