Are TIM proteins involved in asthma development or pathology?
作者信息
Lin J, Kane L P
出版信息
Clin Exp Allergy. 2011 Jul;41(7):917-9. doi: 10.1111/j.1365-2222.2011.03771.x. Epub 2011 May 30.
Abstract
摘要
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Are TIM proteins involved in asthma development or pathology?TIM蛋白是否参与哮喘的发生发展或病理过程？
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本文引用的文献
1
Tim1 and Tim3 are not essential for experimental allergic asthma.Tim1 和 Tim3 对于实验性变应性哮喘并非必需。
Clin Exp Allergy. 2011 Jul;41(7):1012-21. doi: 10.1111/j.1365-2222.2011.03728.x. Epub 2011 Apr 7.
2
Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity.凋亡细胞通过 T 细胞免疫球蛋白样黏蛋白-1 激活 NKT 细胞，导致气道高反应性。
J Immunol. 2010 Nov 1;185(9):5225-35. doi: 10.4049/jimmunol.1001116. Epub 2010 Oct 1.
3
Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma.TIM-1 拮抗作用可阻断过敏性哮喘人源化小鼠模型疾病的发展。
J Clin Invest. 2010 Aug;120(8):2767-81. doi: 10.1172/JCI39543. Epub 2010 Jul 12.
4
Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response.Tim-1 在生发中心 B 细胞中通过 B 细胞受体信号诱导，但对于生发中心反应不是必需的。
Immunology. 2010 Sep;131(1):77-88. doi: 10.1111/j.1365-2567.2010.03276.x. Epub 2010 May 26.
5
T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production.T 细胞免疫球蛋白结构域和黏蛋白结构域 1 与不变自然杀伤 T 细胞的结合在 TCR 刺激存在的情况下增强了 IL-4 的产生，但抑制了 IFN-γ的产生。
J Immunol. 2010 Apr 15;184(8):4095-106. doi: 10.4049/jimmunol.0901991. Epub 2010 Mar 10.
6
Expression of the Th1-specific cell-surface protein Tim-3 increases in a murine model of atopic asthma.在过敏性哮喘小鼠模型中，Th1特异性细胞表面蛋白Tim-3的表达增加。
J Asthma. 2009 Nov;46(9):872-7. doi: 10.3109/02770900903199953.
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Expression of T-cell immunoglobulin- and mucin-domain-containing molecule-1 (TIM-1) is increased in a mouse model of asthma and relationship to GATA-3.在哮喘小鼠模型中，含T细胞免疫球蛋白和粘蛋白结构域分子-1（TIM-1）的表达增加及其与GATA-3的关系。
Life Sci. 2008 Mar 12;82(11-12):663-9. doi: 10.1016/j.lfs.2007.12.017. Epub 2007 Dec 28.
8
TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.TIM-1和TIM-3增强肥大细胞产生Th2细胞因子的能力。
Blood. 2007 Oct 1;110(7):2565-8. doi: 10.1182/blood-2006-11-058800. Epub 2007 Jul 9.
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Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.Tim-1在激活过程中的差异性参与可正向或负向共刺激T细胞扩增和效应功能。
J Exp Med. 2007 Jul 9;204(7):1691-702. doi: 10.1084/jem.20062498. Epub 2007 Jul 2.
10
A functional polymorphism in the TIM-1 gene is associated with asthma in a Chinese Han population.TIM-1基因中的一个功能性多态性与中国汉族人群的哮喘相关。
Int Arch Allergy Immunol. 2007;144(3):197-202. doi: 10.1159/000103992. Epub 2007 Jun 15.
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