Hiroe M, Nagata M, Sekiguchi M, Ohta Y, Kusakabe K, Shigeta A, Horie T, Fujita N, Hasumi M, Toyosaki T
Department of Radiology and Cardiology, Tokyo Women's Medical College.
Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Jan;28(1):56-64.
This study was aimed to determine whether nuclear methods were useful for examining cardiac pathology and for making a decision of corticosteroid therapy in patients with sarcoidosis. Thirty six patients were divided into two groups; GpA consisted of 19 patients with cardiac sarcoidosis and abnormal ECG findings, and GpB of 17 patients with sarcoidosis without ECG abnormalities. Cardiac uptake of 67Ga-citrate in 2 and 99mTc-PYP in one of GpA was observed and steroid therapy resulted in the disappearance of the uptake. 201Tl-CL cardiac tomograms disclosed perfusion defects in 10 of 14 patients (71%) in GpA, including defects with redistribution in 8 of the 10 pts, but only one case in GpB. Radionuclide ventriculography using 99mTc-RBC revealed abnormal response of left ventricular (LV) function to exercise and LV dysfunction in GpA. These data suggest that nuclear study is a useful tool for diagnosing cardiac sarcoidosis, evaluating therapeutic effectiveness and long-term follow-up in patients with sarcoidosis.
本研究旨在确定核医学方法是否有助于检查结节病患者的心脏病变以及决定是否进行皮质类固醇治疗。36例患者被分为两组；A组由19例患有心脏结节病且心电图异常的患者组成，B组由17例结节病但无心电图异常的患者组成。观察到A组中有2例患者心脏摄取67Ga-柠檬酸盐，1例摄取99mTc-PYP，类固醇治疗后摄取消失。201Tl-CL心脏断层扫描显示A组14例患者中有10例（71%）存在灌注缺损，其中10例中有8例存在再分布缺损，但B组仅1例。使用99mTc-RBC进行放射性核素心室造影显示A组左心室（LV）功能对运动的反应异常以及左心室功能障碍。这些数据表明，核医学检查是诊断心脏结节病、评估治疗效果以及对结节病患者进行长期随访的有用工具。
