Department of Nutrition and Food Hygiene, Medical College of Qingdao University, Qingdao, China.
Clin Chim Acta. 2011 Aug 17;412(17-18):1658-61. doi: 10.1016/j.cca.2011.05.019. Epub 2011 May 23.
Serum gamma-glutamyltransferase (GGT) and C-reactive protein(CRP) have been previously shown to be associated with impaired fasting glucose/impaired glucose tolerance (IFG/IGT), but such an association has not been well verified, and is examined in a non-diabetic Chinese population.
A population-based cross-sectional study was conducted in 2006 in Qingdao, China. Data of 1143 men and 1689 women aged 35-74 years and free of diabetes at baseline were analyzed. Multivariable logistic regression analysis was performed to estimate the odds ratio (OR) and its 95% confidence interval (CI).
Compared with the lowest quartile, the ORs (95%CI) for IFG/IGT corresponding to the highest quartile were 0.89(0.61,1.28) in men and 0.87(0.64,1.18) in women for CRP and 2.12(1.40,3.38) and 1.87(1.32,2.62) for GGT, when the two were fitted simultaneously in a model adjusting for age, school years, alcohol-drinking, smoking, family history of diabetes, systolic blood pressure, waist circumference, triglycerides and high-density lipoprotein.
The elevated GGT, but not CRP, was independently associated with the presence of the IFG/IGT in both genders in this Chinese population.
血清γ-谷氨酰转移酶（GGT）和 C 反应蛋白（CRP）先前已被证明与空腹血糖受损/糖耐量受损（IFG/IGT）相关，但这种关联尚未得到很好的验证，并在非糖尿病的中国人群中进行了检查。
2006 年在中国青岛进行了一项基于人群的横断面研究。对基线时无糖尿病的 1143 名男性和 1689 名女性的 35-74 岁数据进行了分析。采用多变量 logistic 回归分析来估计比值比（OR）及其 95%置信区间（CI）。
与 CRP 最低四分位相比，CRP 最高四分位对应的 IFG/IGT 的 OR（95%CI）在男性中为 0.89（0.61,1.28），在女性中为 0.87（0.64,1.18）；GGT 对应的 OR（95%CI）在男性中为 2.12（1.40,3.38），在女性中为 1.87（1.32,2.62），当同时在一个模型中调整年龄、受教育年限、饮酒、吸烟、糖尿病家族史、收缩压、腰围、甘油三酯和高密度脂蛋白时。
在该中国人群中，GGT 升高（但 CRP 不升高）与男女 IFG/IGT 的存在独立相关。
