Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia.
Spinal Cord. 2011 Oct;49(10):1036-41. doi: 10.1038/sc.2011.60. Epub 2011 May 31.
Animal proof of principle study.
To determine whether capromorelin, a compound that causes defecation by stimulating ghrelin receptors within the lumbosacral defecation centers, is effective after spinal cord injury (SCI), and whether SCI significantly alters sensitivity to the compound.
University of Melbourne and Austin Hospital, Melbourne, Australia.
Rats were subjected to spinal cord contusion injury or were sham-operated. At 6 weeks after surgery, effects of capromorelin on blood pressure, heart rate and propulsive contractions of the colorectum were investigated.
Capromorelin caused robust propulsive activity in the colorectum soon after its application. The compound was similarly effective in naïve, sham-operated and spinal cord-injured rats. Blood pressure increases caused by capromorelin were not exaggerated after SCI, and there was no evidence of phasic blood pressure increases when the colon was contracted by the compound.
Capromorelin is a therapeutic compound that could potentially be used to relieve constipation by triggering defecation in spinal cord-injured patients.
动物原理验证研究。
确定卡泊瑞林（一种通过刺激腰骶排便中枢内的胃饥饿素受体引起排便的化合物）在脊髓损伤（SCI）后是否有效，以及 SCI 是否显著改变了对该化合物的敏感性。
澳大利亚墨尔本大学和奥斯汀医院。
大鼠接受脊髓挫伤损伤或假手术。手术后 6 周，研究卡泊瑞林对血压、心率和结肠推进性收缩的影响。
卡泊瑞林给药后不久即可引起结肠强烈的推进性活动。该化合物在未处理、假手术和脊髓损伤大鼠中同样有效。SCI 后卡泊瑞林引起的血压升高并未加剧，并且当结肠被该化合物收缩时，没有出现血压呈阶段性升高的证据。
卡泊瑞林是一种治疗性化合物，可通过触发脊髓损伤患者排便来缓解便秘。
