Department of Physiology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
Indian J Pediatr. 2011 Nov;78(11):1407-9. doi: 10.1007/s12098-011-0456-3. Epub 2011 May 28.
The present analytic study was planned to study the impact of overweight and obesity on glucose tolerance in adolescents. Thirty overweight (BMI analogue ≥ 25-29.9 kg/m(2)) and 30 obese (BMI analogue ≥ 30 kg/m(2)) adolescents were included as cases and 30 healthy age and sex matched adolescents comprised the control group. All the study participants were subjected to oral glucose tolerance test (OGTT) as a measure of glucose tolerance.Means of fasting blood glucose levels in normal, overweight and obese groups were 84.5 mg/dl, 86.7 mg/dl and 94.8 mg/dl respectively. Means of two hourly blood glucose levels in normal, overweight and obese groups were 105.8 mg/dl, 117 mg/dl and 127.1 mg/dl respectively. Oral Glucose tolerance test (OGTT) was normal in all the participants from control group but was impaired in four overweight adolescents. In obese group, OGTT was impaired in eight subjects and one obese child had fasting and 2 hourly blood glucose levels in diabetic range.
本分析研究旨在研究超重和肥胖对青少年葡萄糖耐量的影响。将 30 名超重（BMI 模拟值≥25-29.9 kg/m²）和 30 名肥胖（BMI 模拟值≥30 kg/m²）青少年作为病例纳入研究，另外 30 名年龄和性别相匹配的健康青少年作为对照组。所有研究参与者均接受口服葡萄糖耐量试验（OGTT）以评估葡萄糖耐量。正常、超重和肥胖组的空腹血糖水平平均值分别为 84.5 mg/dl、86.7 mg/dl 和 94.8 mg/dl。正常、超重和肥胖组的两小时后血糖水平平均值分别为 105.8 mg/dl、117 mg/dl 和 127.1 mg/dl。对照组所有参与者的 OGTT 均正常，但 4 名超重青少年的 OGTT 受损。在肥胖组中，8 名受试者的 OGTT 受损，1 名肥胖儿童的空腹和两小时后血糖水平处于糖尿病范围内。
