"Polish Mother's Health Center" Research Institute, Lodz, Poland.
Arch Immunol Ther Exp (Warsz). 2011 Aug;59(4):289-99. doi: 10.1007/s00005-011-0131-4. Epub 2011 May 28.
The process of chronic inflammation is a common link which connects different kinds of environmental pollutants and infections with tumorigenesis. Transcription factor NF-κB is a common final target for many inflammatory and cell proliferation pathways, independent of the source of stimuli (e.g., cytokines, growth factors, environmental carcinogens, radiation, hypoxia, bacteria, and viruses). Over-activation of NF-κB has been confirmed in many tumors, resulting in worse prognosis for patient survival. Therefore, inhibition of cellular pathways for NF-κB activation is nowadays considered as a promising anti-cancer therapy and is extensively studied in clinical trials, or even has been adopted as an approved therapy in some kinds of cancer.
慢性炎症的发生过程是一个共同的环节，它将不同类型的环境污染物和感染与肿瘤发生联系起来。转录因子 NF-κB 是许多炎症和细胞增殖途径的共同最终靶点，而与刺激源（例如细胞因子、生长因子、环境致癌物、辐射、缺氧、细菌和病毒）无关。在许多肿瘤中已经证实 NF-κB 的过度激活，导致患者生存预后更差。因此，抑制 NF-κB 激活的细胞途径被认为是一种有前途的抗癌治疗方法，目前正在临床试验中广泛研究，甚至在某些类型的癌症中已被采用为一种批准的治疗方法。
