Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, British Columbia, Canada.
Mov Disord. 2011 May;26(6):868-978. doi: 10.1002/mds.23679.
In the last 25 years there have been enormous advances in brain imaging. In addition to utility in diagnosis, these have led to novel insights into the pathogenesis of basal ganglia disease and the role of dopamine and the basal ganglia in normal health. The authors review highlights of this work, with a focus on advances in Parkinson's disease, the dystonias, Huntington's disease, and the role of dopamine in cognition and reward signaling. Emerging areas for future development include studies of functional connectivity, the analysis of default mode networks, studies of novel neurochemical pathways, methods to study disease pathogenesis, and the application of imaging techniques to investigate animal models of disease.
在过去的 25 年中，脑成像技术取得了巨大的进展。除了在诊断中的应用外，这些进展还使我们对基底神经节疾病的发病机制以及多巴胺和基底神经节在正常健康中的作用有了新的认识。作者回顾了这项工作的重点，主要集中在帕金森病、肌张力障碍、亨廷顿病以及多巴胺在认知和奖励信号中的作用方面的进展。未来发展的新兴领域包括功能连接的研究、默认模式网络的分析、新型神经化学途径的研究、研究疾病发病机制的方法以及将成像技术应用于疾病动物模型的研究。
