Blood-Brain Interactions Group, School of Psychology and Psychiatry, Monash University, Clayton, Victoria, Australia.
Int J Geriatr Psychiatry. 2012 May;27(5):463-71. doi: 10.1002/gps.2736. Epub 2011 May 27.
The Mini-Mental State Examination (MMSE) is commonly used as a screening test for dementia, yet MMSE scores above the cut-off for dementia (24-30) are widely thought to have limited utility, particularly in older persons. The study investigates whether scores within this range can be indicative of pre-symptomatic levels of cognitive impairment.
Ninety-six community-dwelling older persons aged 62-89 years (mean = 75.2 years), who had obtained MMSE scores between 25 and 30, were tested on the computer-based Subtle Cognitive Impairment Test (SCIT).
Compared with individuals who obtained a perfect score of 30 on the MMSE, individuals with scores of 28-29 made more errors on the SCIT, whereas those with scores of 25-27 on the MMSE made the most errors on the SCIT (F(2,94) = 9.84, p < 0.01). Individuals who made errors in the language (r(94) = -0.47, p < 0.01), attention (r(94) = 0.24, p < 0.05) and visual construction (r(94) = -0.27, p < 0.01) subtests of the MMSE were more likely to display impaired SCIT performance.
The pattern of performance on the SCIT varied in a systematic way, depending on the MMSE subtest in which the errors were made, raising the possibility that there may be different subtypes of subtle cognitive impairment within the ostensibly normal population of older persons.
简易精神状态检查（MMSE）常用于痴呆症的筛查测试，但人们普遍认为，MMSE 得分高于痴呆症的临界值（24-30）的实用性有限，尤其是在老年人中。本研究旨在探讨该范围内的分数是否可以提示无症状认知障碍的水平。
96 名年龄在 62-89 岁（平均 75.2 岁）、MMSE 得分在 25-30 分之间的社区居住的老年人接受了基于计算机的隐匿性认知障碍测试（SCIT）的测试。
与 MMSE 获得满分 30 的个体相比，MMSE 得分 28-29 的个体在 SCIT 上的错误更多，而 MMSE 得分 25-27 的个体在 SCIT 上的错误最多（F(2,94) = 9.84，p < 0.01）。在 MMSE 的语言（r(94) = -0.47，p < 0.01）、注意力（r(94) = 0.24，p < 0.05）和视觉建构（r(94) = -0.27，p < 0.01）子测试中出现错误的个体更有可能表现出 SCIT 表现受损。
SCIT 的表现模式以系统的方式变化，这取决于出现错误的 MMSE 子测试，这表明在看似正常的老年人群体中，可能存在不同类型的隐匿性认知障碍。
