从其cDNA推导的人碱性成纤维细胞生长因子受体较短形式的完整氨基酸序列。
The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA.
作者信息
Itoh N, Terachi T, Ohta M, Seo M K
机构信息
Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
出版信息
Biochem Biophys Res Commun. 1990 Jun 15;169(2):680-5. doi: 10.1016/0006-291x(90)90384-y.
We have isolated a full-length cDNA for human basic fibroblast growth factor (bFGF) receptor-like protein from a human placenta cDNA library. Determination of the nucleotide sequence of the cDNA allows elucidation of the complete amino acid sequence of the receptor (731 amino acids) which has two extracellular immunoglobulin-like domains, a transmembrane domain and an intracellular tyrosine kinase domain. The receptor has remarkable amino acid similarity (98% identity) to the shorter form of murine bFGF receptor reported recently (H.H. Reid et al. (1990) Proc.Natl.Acad.Sci. USA 87, 1596-1600). The receptor described here is expected to be the shorter form of human bFGF receptor.
我们从人胎盘cDNA文库中分离出了人碱性成纤维细胞生长因子（bFGF）受体样蛋白的全长cDNA。对该cDNA核苷酸序列的测定，使我们能够阐明该受体完整的氨基酸序列（731个氨基酸），它具有两个细胞外免疫球蛋白样结构域、一个跨膜结构域和一个细胞内酪氨酸激酶结构域。该受体与最近报道的小鼠bFGF受体较短形式具有显著的氨基酸相似性（98%相同）（H.H.里德等人（1990年），《美国国家科学院院刊》87卷，第1596 - 1600页）。这里描述的受体有望成为人bFGF受体的较短形式。
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