双侧肾上腺切除术对大鼠肠上皮细胞中血管活性肠肽受体/效应系统的影响。
Effect of bilateral adrenalectomy on VIP receptor/effector system in rat intestinal epithelial cells.
作者信息
Fernández-Moreno M D, Carrero I, Arilla E, Prieto J C
机构信息
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Madrid, Spain.
出版信息
Biosci Rep. 1990 Apr;10(2):165-71. doi: 10.1007/BF01116575.
The number of vasoactive intestinal peptide (VIP) receptors and the efficiency of VIP in the stimulation of cyclic AMP accumulation in rat jejunal epithelial cells increased after bilateral adrenalectomy. However, this condition increased neither receptor affinity nor VIP potency. In addition, jejunal VIP levels followed a parallel increase. These changes reversed to control conditions after glucocorticoid replacement with dexamethasone indicating that adrenalectomy modifies the intestinal VIP receptor/effector system and suggest a relationship between corticosteroids and VIP in the functions of intestinal epithelium.
双侧肾上腺切除术后，大鼠空肠上皮细胞中血管活性肠肽（VIP）受体的数量以及VIP刺激环磷酸腺苷（cAMP）积累的效率均有所增加。然而，这种情况既未增加受体亲和力，也未提高VIP的效能。此外，空肠VIP水平也呈平行升高。用 dexamethasone 进行糖皮质激素替代后，这些变化恢复至对照状态，这表明肾上腺切除术改变了肠道VIP受体/效应系统，并提示在肠道上皮功能中，皮质类固醇与VIP之间存在关联。
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