Roberts E L, Rosenthal M, Sick T J
Department of Neurology, University of Miami School of Medicine, FL 33101.
Brain Res. 1990 Apr 23;514(1):111-8. doi: 10.1016/0006-8993(90)90441-d.
Age-related changes in the capacity of the brain to survive short anoxic episodes were studied in stratum pyramidale (region CA1) of hippocampal slices from control (6-7 months) and aged (26-27 months) rats. Our primary interest was in how aging affected the ability of slices to maintain or to recover extracellular potassium ion (K+o) homeostasis and orthodromically-stimulated field potentials during and after anoxia. During anoxia, K+o homeostasis was lost faster in slices from aged rats. Following anoxia, K+o homeostasis recovered more slowly, and synaptic transmission recovered less completely, in aged slices. These studies provide what is believed to be the first demonstration that aging diminishes the capacity of brain tissue to maintain K+o during anoxia and to recover K+o homeostasis and synaptic transmission following anoxia, and support suggestions that the aged brain is more vulnerable to anoxia.
在来自对照（6 - 7个月）和老年（26 - 27个月）大鼠的海马切片锥体层（CA1区）中，研究了大脑在短期缺氧发作时存活能力的年龄相关变化。我们主要关注的是衰老如何影响切片在缺氧期间及之后维持或恢复细胞外钾离子（K+o）稳态以及顺向刺激场电位的能力。在缺氧期间，老年大鼠切片中K+o稳态丧失得更快。缺氧后，老年切片中K+o稳态恢复得更慢，并且突触传递恢复得更不完全。这些研究首次证明了衰老会降低脑组织在缺氧期间维持K+o的能力以及缺氧后恢复K+o稳态和突触传递的能力，并支持了老年大脑更容易受到缺氧影响的观点。
