围产期暴露于地西泮后低亲和力γ-氨基丁酸A型受体的区域特异性改变。

Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam.

作者信息

Gruen R J, Elsworth J D, Roth R H

机构信息

Department of Psychology, New York University, New York 10003.

出版信息

Brain Res. 1990 Apr 23;514(1):151-4. doi: 10.1016/0006-8993(90)90449-l.

DOI:10.1016/0006-8993(90)90449-l

PMID:2162709

Abstract

Alterations in a low affinity form of the GABAA receptor were examined with [3H]bicuculline methylchloride in the adult rat following perinatal exposure to diazepam. Perinatal exposure resulted in a significant reduction in [3H]bicuculline binding in the cingulate cortex. A significant decrease in the ability of GABA to displace bound [3H]bicuculline was observed only in the hypothalamus. The results suggest that the effects of perinatal exposure to diazepam are regionally specific and that benzodiazepine receptors and low affinity GABAA receptors are functionally linked during the perinatal period.

摘要

在成年大鼠围产期暴露于地西泮后，用[3H]甲基荷包牡丹碱研究了GABAA受体低亲和力形式的变化。围产期暴露导致扣带回皮质中[3H]甲基荷包牡丹碱结合显著减少。仅在下丘脑中观察到GABA置换结合的[3H]甲基荷包牡丹碱的能力显著降低。结果表明，围产期暴露于地西泮的影响具有区域特异性，并且苯二氮䓬受体和低亲和力GABAA受体在围产期功能上是相关联的。