DXS26（HU16）位于Xq21.1。
DXS26 (HU16) is located in Xq21.1.
作者信息
Sankila E M, Bruns G A, Schwartz M, Nikoskelainen E, Niebuhr E, Hodgson S V, Wright A F, de la Chapelle A
机构信息
Department of Medical Genetics, University of Helsinki, Finland.
出版信息
Hum Genet. 1990 Jun;85(1):117-20. doi: 10.1007/BF00276335.
We have localized a single-copy DNA probe, HU16 (locus DXS26), to Xq21.1. The probe was isolated from a human-mouse hybrid X;13 library and mapped with human-mouse hybrids containing different portions of the human X chromosome and DNA from male patients with different X-chromosomal deletions. The following order of loci is proposed: Xcen-(DXS72,DXS169)-(DXS232,DSX26)-DXS1 21-DXS233-DXS165-TCD-DXS95-DXYS1-Xqter. HU16 will be useful in the study of the putative genes that reside in Xq21 and whose defects lead to deafness and mental retardation.
我们已将一个单拷贝DNA探针HU16（基因座DXS26）定位到Xq21.1。该探针是从一个人-鼠杂种X;13文库中分离出来的，并利用含有人类X染色体不同部分的人-鼠杂种以及来自患有不同X染色体缺失的男性患者的DNA进行了定位。提出了以下基因座顺序：Xcen - (DXS72, DXS169) - (DXS232, DSX26) - DXS121 - DXS233 - DXS165 - TCD - DXS95 - DXYS1 - Xqter。HU16将有助于研究位于Xq21且其缺陷导致耳聋和智力迟钝的假定基因。
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