鞘内注射巴氯芬对继发全面性痉挛儿童日常护理的影响：一项初步研究。
Effects of intrathecal baclofen on daily care in children with secondary generalized dystonia: a pilot study.
机构信息
Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands.
出版信息
Eur J Paediatr Neurol. 2011 Nov;15(6):539-43. doi: 10.1016/j.ejpn.2011.05.003. Epub 2011 May 31.
AIM
Treatment options for dystonic cerebral palsy (CP) are limited. Our aims were to determine whether intrathecal baclofen (ITB) improves daily care, decreases dystonia and decreases pain in patients with dystonic CP.
METHODS
Patients received randomized blinded treatment with ITB or placebo. Scores on problems of daily care were recorded and dystonia, pain and comfort were assessed.
RESULTS
Four patients (three males, average age 12 years 6 months) were included (all Gross Motor Function Classification System level V). During the trial period problem scores and dystonia scores decreased in all four patients.
CONCLUSION
In this pilot study we report positive functional effects of ITB trial treatment in four patients with dystonic CP. A randomized trial with a larger cohort is needed to verify these results.
目的
扭转型脑瘫（CP）的治疗选择有限。我们的目的是确定鞘内巴氯芬（ITB）是否能改善日常护理、减轻扭转痉挛和减轻扭转型 CP 患者的疼痛。
方法
患者接受 ITB 或安慰剂的随机盲法治疗。记录日常生活问题的评分，并评估扭转痉挛、疼痛和舒适度。
结果
4 名患者（3 名男性，平均年龄 12 岁 6 个月）入组（所有粗大运动功能分类系统均为 5 级）。在试验期间，所有 4 名患者的问题评分和扭转痉挛评分均降低。
结论
在这项初步研究中，我们报告了 ITB 试验治疗对 4 名扭转型 CP 患者的积极功能影响。需要一项更大队列的随机试验来验证这些结果。
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