Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11-222, Palmerston North, 4442, New Zealand.
Vet Rec. 2011 Jun 4;168(22):588. doi: 10.1136/vr.d1191. Epub 2011 May 31.
Butorphanol tartrate (2 mg/kg) was injected intravenously in 18 healthy broiler chickens to study its pharmacokinetics. Plasma samples were analysed by a highly sensitive high-performance liquid chromatography with diode-array detection method and pharmacokinetic parameters were calculated from the mean pooled data. With non-compartmental analysis, the terminal half-life (T(1/2.z)) was 71.3 minutes, clearance was 67.6 ml/minute/kg and the apparent volume of distribution was 6.9 l/kg. The concentration-time curve was also fitted to a two-compartmental model. In this analysis, elimination half-life (T(1/2β)) was 69.3 minutes, clearance was 74.6 ml/minute/kg and volume of distribution at steady state was 5.6 l/kg. The micro rate constants k(21), k(12) and k(10) were 0.034, 0.050 and 0.029, respectively. Butorphanol was well distributed in the chickens with rapid clearance. It remained above the minimum effective concentration for analgesia in mammals for approximately two hours in the chickens.
酒石酸布托啡诺（2 毫克/公斤）被静脉注射到 18 只健康肉鸡中，以研究其药代动力学。通过高效液相色谱二极管阵列检测法对血浆样本进行分析，并从平均汇总数据中计算药代动力学参数。采用非房室分析，末端半衰期（T(1/2.z)）为 71.3 分钟，清除率为 67.6ml/min/kg，表观分布容积为 6.9l/kg。浓度-时间曲线也拟合为二房室模型。在该分析中，消除半衰期（T(1/2β)）为 69.3 分钟，清除率为 74.6ml/min/kg，稳态分布容积为 5.6l/kg。微速率常数 k(21)、k(12)和 k(10)分别为 0.034、0.050 和 0.029。布托啡诺在鸡体内分布良好，清除率较快。它在鸡体内的镇痛作用持续时间约为两小时，超过了哺乳动物的最低有效浓度。
