Ohta Yoichi, Iwamoto Masahiro
Department of Surgery, The Children's Hospital of Philadelphia Research Institute, PA, USA.
Clin Calcium. 2011 Jun;21(6):813-9.
During limb skeletogenesis progenitor mesenchymal cells aggregate at specific times and sites to form continuous precartilaginous condensations. With time the condensations undergo chondrogenesis and give rise to cartilaginous anlagen that exhibit incipient synovial joints at each end. A multitude of factors regulates subdivision into discrete skeletal elements and the formation, organization, morphogenesis and structure of the joints. This review summarizes recent advance of joint morphogenesis and actions of key players of joint and articular cartilage formation. In addition, we would like to discuss possible direction to translate basic research findings towards treatment of joint diseases.
在肢体骨骼发生过程中，祖间充质细胞在特定时间和部位聚集，形成连续的软骨前凝聚物。随着时间的推移，这些凝聚物经历软骨形成，产生软骨原基，其两端呈现出初始的滑膜关节。多种因素调节其细分为离散的骨骼元素以及关节的形成、组织、形态发生和结构。本综述总结了关节形态发生的最新进展以及关节和关节软骨形成关键参与者的作用。此外，我们还想讨论将基础研究成果转化为关节疾病治疗方法的可能方向。
