K⁺-Cl⁻ 共转运体在胃壁细胞酸分泌机制中的作用。
Function of K⁺-Cl⁻ cotransporters in the acid secretory mechanism of gastric parietal cells.
机构信息
Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
出版信息
Biol Pharm Bull. 2011;34(6):810-2. doi: 10.1248/bpb.34.810.
Gastric proton pump (H⁺, K⁺-ATPase) secretes H⁺ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl⁻- and K⁺-transporting proteins are required. Recent our studies have demonstrated that K⁺-Cl⁻ cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na⁺, K⁺-ATPase in the basolateral membrane, and KCC4 is associated with H⁺, K⁺-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.
胃质子泵（H⁺，K⁺-ATPase）通过壁细胞的腔膜分泌酸（HCl）中的 H⁺。对于 HCl 的分泌，需要 Cl⁻和 K⁺转运蛋白。最近的研究表明，胃壁细胞中表达 K⁺-Cl⁻共转运体（KCC3a 和 KCC4）。KCC3a 与基底外侧膜中的 Na⁺，K⁺-ATPase 相关，而 KCC4 与顶端腔膜中的 H⁺，K⁺-ATPase 相关。本文总结了 KCCs 与 P 型 ATPase 之间的功能关联，以及这些复合物对胃壁细胞中胃酸分泌的贡献。
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