双（恶唑啉基）吡啶铱配合物催化的用活性较低的 N-或 O-亲核试剂进行的区域和对映选择性烯丙基取代反应
Regio- and enantioselective allylic substitution with less active N- or O-nucleophiles catalyzed by iridium-complex of bis(oxazolinyl)pyridine.
作者信息
Miyabe Hideto, Moriyama Katsuhiko, Takemoto Yoshiji
机构信息
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2011;59(6):714-20. doi: 10.1248/cpb.59.714.
The utility of hydroxylamines as nitrogen nucleophiles was investigated in the iridium-catalyzed regio- and enantioselective allylic substitution. Allylic substitution with hydroxylamines proceeded with good enantioselectivities by using the iridium-complex of bis(oxazolinyl)pyridine ligand. The good regio- and enantioselectivities were also achieved in the reaction with alkylamines, p-anisidine, and 4-methoxyphenol.
在铱催化的区域和对映选择性烯丙基取代反应中，研究了羟胺作为氮亲核试剂的效用。通过使用双（恶唑啉基）吡啶配体的铱配合物，羟胺的烯丙基取代反应具有良好的对映选择性。在与烷基胺、对甲氧基苯胺和4-甲氧基苯酚的反应中也实现了良好的区域和对映选择性。
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