Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (sez. Biologia Cellulare), Università degli Studi di Palermo, Palermo, Italy.
Autophagy. 2011 Sep;7(9):1028-34. doi: 10.4161/auto.7.9.16450. Epub 2011 Sep 1.
It is well known that sea urchin embryos are able to activate different defense strategies against stress. We previously demonstrated that cadmium treatment triggers the accumulation of metal in embryonic cells and the activation of defense systems depending on concentration and exposure time, through the synthesis of heat shock proteins and/or the initiation of apoptosis. Here we show that Paracentrotus lividus embryos exposed to Cd adopt autophagy as an additional stratagem to safeguard the developmental program. At present, there are no data focusing on the role of this process in embryo development of marine organisms.
众所周知，海胆胚胎能够针对压力激活不同的防御策略。我们之前的研究表明，镉处理通过热休克蛋白的合成和/或凋亡的启动，根据浓度和暴露时间，触发金属在胚胎细胞中的积累和防御系统的激活。在这里，我们表明，暴露于 Cd 的 P. lividus 胚胎采用自噬作为保护发育程序的另一种策略。目前，尚无数据聚焦于该过程在海洋生物胚胎发育中的作用。
