Lloyd K G, Pichat P, Scatton B, Zivkovic B, Morselli P L, Bartholini G
Synthélabo Recherche (L.E.R.S.), Paris, France.
J Neural Transm Suppl. 1990;29:13-28. doi: 10.1007/978-3-7091-9050-0_3.
Recent advances in the psychopharmacology of GABA synapses are reviewed. The usefulness of GABA mimetics in tardive dyskinesia and epilepsy has been confirmed, as has a dysfunction of GABA synapses in the etiopathology of these conditions. The antidepressant profile of GABA agonists in animal models for depression has been extended. The role of GABA receptors in the mechanism of action of antidepressants has been further delineated, with a parallelism occurring between the behavioral and biochemical response to antidepressant drug treatment in different animal models of depression.
本文综述了γ-氨基丁酸（GABA）突触心理药理学的最新进展。GABA模拟物在迟发性运动障碍和癫痫中的效用已得到证实，这些病症的病因学中也存在GABA突触功能障碍。GABA激动剂在抑郁症动物模型中的抗抑郁特性已得到拓展。GABA受体在抗抑郁药作用机制中的作用已得到进一步阐明，在不同抑郁症动物模型中，抗抑郁药物治疗的行为反应和生化反应之间存在平行关系。
