Demir Yavuz, Aktepe Fatma, Kandal Sebahattin, Sancaktar Nazli, Turhan-Haktanir Nurten
Department of Plastic, Reconstructive and Aesthetic Surgery, Afyon Kocatepe University, School of Medicine, Afyon, Turkey.
Ann Plast Surg. 2012 Mar;68(3):308-13. doi: 10.1097/SAP.0b013e318214534f.
Due to its unique composition, the reconstruction of scrotal skin defects is a major clinical challenge. This study was designed to evaluate the effects of scrotal reconstruction, using skin grafts and skin flaps, on spermatogenesis. In Group 1, the rats did not undergo surgery and were used as controls. In Group 2, after removal of all of the scrotal skin to expose the testicles, the defect was repaired using a skin flap from the right groin region. In Group 3, the reconstruction was achieved using skin grafts. All the rats were killed at 2 months postoperatively and evaluated. The mean wet weights of the testicles in the control group were significantly higher compared with that of the graft group. The mean height of the germinal epithelium was significantly greater in the control and flap groups compared with that of the graft group. The Johnsen score for spermatogenesis in the control group was higher than that in the graft group. The use of flaps resulted in testicular function that was comparable to that of the control group, whereas the use of grafts resulted in diminished testicular function. Therefore, we suggest that flaps may be the first choice for scrotal reconstruction.
由于阴囊皮肤缺损的独特构成，其重建是一项重大的临床挑战。本研究旨在评估使用皮肤移植和皮瓣进行阴囊重建对精子发生的影响。在第1组中，大鼠未接受手术，用作对照。在第2组中，切除所有阴囊皮肤以暴露睾丸后，使用右侧腹股沟区的皮瓣修复缺损。在第3组中，使用皮肤移植进行重建。所有大鼠在术后2个月处死并进行评估。与移植组相比，对照组睾丸的平均湿重显著更高。与移植组相比，对照组和皮瓣组的生精上皮平均高度显著更大。对照组精子发生的约翰森评分高于移植组。使用皮瓣导致睾丸功能与对照组相当，而使用移植则导致睾丸功能减退。因此，我们建议皮瓣可能是阴囊重建的首选。
