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VP-16, vincristine and procarbazine with radiation therapy for treatment of malignant brain tumors.

作者信息

Hellman R M, Calogero J A, Kaplan B M

机构信息

Department of Neurosurgery and Radiation Oncology, St. Francis Hospital and Medical Center, Hartford, Connecticut.

出版信息

J Neurooncol. 1990 Apr;8(2):163-6. doi: 10.1007/BF00177840.

DOI:10.1007/BF00177840
PMID:2162915
Abstract

Twelve patients aged 34 to 65 with malignant gliomas were treated with VP-16, Procarbazine, Vincristine and concurrent radiation therapy. There were 9 patients with glioblastoma multiforme and 3 with anaplastic astrocytoma. All patients had a subtotal resection or biopsy as the initial procedure. Six patients (1 anaplastic astrocytoma) have developed progressive disease. Mean time to tumor progression was 46 weeks. This combined modality treatment program was associated with reversible hematologic toxicity which was severe in 2 patients. These data compare favorably to data obtained from similar patients treated with radiation therapy and BCNU.

摘要

相似文献

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引用本文的文献

1
A therapeutic trial of radiation therapy with Vincristine, etoposide, and Procarbazine (VVP) in high grade intracranial gliomas--an Eastern Cooperative Oncology Group Study (E2392).
J Neurooncol. 1998 Mar;37(1):55-62. doi: 10.1023/a:1005867520788.
2
In vitro chemosensitivity test of human brain tumors using a three-dimensional organ culture with a collagen gel matrix.使用含胶原凝胶基质的三维器官培养法对人脑肿瘤进行体外化学敏感性测试。
J Neurooncol. 1994;21(3):225-32. doi: 10.1007/BF01063771.
3
Attempted dose intensified cyclophosphamide, etoposide, and granulocyte colony-stimulating factor for treatment of malignant astrocytoma.尝试使用剂量强化的环磷酰胺、依托泊苷和粒细胞集落刺激因子治疗恶性星形细胞瘤。

本文引用的文献

1
Brain tumor chemotherapy: an evaluation of agents in current use for phase II and III trials.脑肿瘤化疗：对目前用于II期和III期试验的药物的评估。
Cancer Treat Rep. 1980;64(12):1179-205.
2
Etoposide (VP-16-213) in malignant brain tumors: a phase II study.依托泊苷（VP - 16 - 213）用于恶性脑肿瘤：一项II期研究。
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Synergistic antitumor activity of vincristine and VP-16-213.长春新碱与依托泊苷的协同抗肿瘤活性。
J Neurooncol. 1995;24(3):285-92. doi: 10.1007/BF01052845.
4
Neuro-oncology index and review (adult primary brain tumors). Radiotherapy, chemotherapy, immunotherapy, photodynamic therapy.神经肿瘤学索引与综述（成人原发性脑肿瘤）。放射治疗、化学疗法、免疫疗法、光动力疗法。
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5
Treatment of early recurrent medulloblastoma in children with cisplatin and etoposide: a preliminary report.顺铂和依托泊苷治疗儿童早期复发性髓母细胞瘤：初步报告。
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Lack of potentiation of vincristine-induced neurotoxicity by VP-16-213.依托泊苷（VP - 16 - 213）不会增强长春新碱诱导的神经毒性。
Am J Clin Oncol. 1983 Jun;6(3):327-30. doi: 10.1097/00000421-198306000-00013.
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Prolongation of survival for high-grade malignant gliomas with adjuvant high-dose BCNU and autologous bone marrow transplantation.辅助大剂量卡氮芥及自体骨髓移植延长高级别恶性胶质瘤患者生存期
J Clin Oncol. 1987 May;5(5):783-9. doi: 10.1200/JCO.1987.5.5.783.
6
Does chemotherapy benefit the patient with a central nervous system glioma?化疗对中枢神经系统胶质瘤患者有益吗？
Oncology (Williston Park). 1987 Nov;1(9):29-36, 40-1.
7
Phase III comparison of BCNU and the combination of procarbazine, CCNU, and vincristine administered after radiotherapy with hydroxyurea for malignant gliomas.恶性胶质瘤放疗后应用卡莫司汀与丙卡巴肼、洛莫司汀和长春新碱联合羟基脲的III期比较。
J Neurosurg. 1985 Aug;63(2):218-23. doi: 10.3171/jns.1985.63.2.0218.