Endocrinology and Cardiovascular Disease Center, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Pediatr Res. 2011 Sep;70(3):307-12. doi: 10.1203/PDR.0b013e318225f8a9.
Childhood adiposity is increasingly recognized as a significant predictor of cardiometabolic risks in later life. The aim of this study was to investigate factors associated with longitudinal changes in weight during childhood and the development of metabolic disease risk factors. Four hundred twenty-four children from DaQing city, China, were recruited at 5 y old and followed up for 5 y. Birth weight, television (TV) viewing time at 5 y old, blood pressure, anthropometric measurements, fasting plasma insulin (FI), and triglycerides (TG) levels were measured at 5 and 10 y old. Both birth weight and TV viewing time at 5 y old significantly correlated with percentage of ideal weight for height (WFH) at 5 y old (WFH5; p = 0.0032 and p = 0.01), but only TV time was significantly correlated with WFH at 10 y old (WFH10; p < 0.0001). Blood pressures, FI, homeostasis model assessment for insulin resistance (HOMA-IR), and TG at 10 y old were significantly greater in those children who had greater change in WFH from 5 to 10 y old (ΔWFH). We concluded that TV viewing time was the stronger determinant of later childhood adiposity. A greater ΔWFH was associated with increased cardiometabolic risk factors at 10 y old.
儿童肥胖症日益被认为是成年后患心血管代谢疾病风险的重要预测因素。本研究旨在探讨儿童期体重纵向变化的相关因素以及代谢疾病风险因素的发展。在中国大庆市，424 名儿童在 5 岁时被招募，并随访 5 年。在 5 岁和 10 岁时测量了出生体重、5 岁时看电视（TV）时间、血压、人体测量学指标、空腹血浆胰岛素（FI）和甘油三酯（TG）水平。出生体重和 5 岁时看电视时间均与 5 岁时身高理想体重百分比（WFH5；p=0.0032 和 p=0.01）显著相关，但只有看电视时间与 10 岁时的 WFH 显著相关（WFH10；p<0.0001）。10 岁时的血压、FI、胰岛素抵抗评估的稳态模型（HOMA-IR）和 TG 均显著高于 WFH 从 5 岁到 10 岁变化较大的儿童（ΔWFH）。我们得出的结论是，看电视时间是后来儿童肥胖的更强决定因素。更大的 ΔWFH 与 10 岁时增加的心血管代谢危险因素相关。
