Lampl Y, Eshel Y, Gilad R, Sarova-Pinchas I
Department of Neurology, Edith Wolfson Medical Center, Holon, Israel.
J Neurooncol. 1990 Apr;8(2):167-72. doi: 10.1007/BF00177841.
Remote metastases, leptomeningeal dissemination and spreading of the tumor by infiltration are rare complications of glioblastoma multiforme. The existence of different forms of spreading simultaneously is very rare. We present a case of a young patient with glioblastoma multiforme who was operated and subsequently received radiation therapy and cytotoxic treatment. Eight months following the operation, the patient developed cauda equina syndrome. Bone metastases of vertebrae and ribs, and direct infiltration of the recurrent tumor mass into the ethmoidal and frontal sinuses were found. The described patient demonstrates a very rare combination of all forms of spreading metastases in glioblastoma multiforme. The infiltration of the tumor mass into the sinuses and the direct permeation of the meningeal and dural venous system and of the leptomeninges, may explain the mechanism of the development of distant metastases and leptomeningeal dissemination in glioblastoma multiforme.
远处转移、软脑膜播散以及肿瘤浸润性扩散是多形性胶质母细胞瘤罕见的并发症。同时存在不同形式的扩散极为罕见。我们报告一例多形性胶质母细胞瘤的年轻患者，该患者接受了手术，随后接受了放射治疗和细胞毒性治疗。术后八个月，患者出现马尾综合征。发现椎体和肋骨骨转移，以及复发性肿瘤块直接浸润筛窦和额窦。所描述的患者展示了多形性胶质母细胞瘤中所有形式的转移性扩散的一种非常罕见的组合。肿瘤块浸润至鼻窦以及软脑膜和硬脑膜静脉系统及软脑膜的直接渗透，可能解释了多形性胶质母细胞瘤远处转移和软脑膜播散的发生机制。
