Goyal Pankaj, Gill S, Gupta U D, Rath Goutam, Narang Raj K, Goyal Amit K
Nanomedicine Research Centre, Department of Pharmaceutics, Indo-Soviet Friendship College of Pharmacy, Moga (Punjab), India.
Artif Cells Blood Substit Immobil Biotechnol. 2011 Oct;39(5):330-4. doi: 10.3109/10731199.2011.573482. Epub 2011 Jun 2.
Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs.
胃滞留型漂浮微球具有提高药物生物利用度和控制药物释放的潜力。本研究旨在开发利福平漂浮微球，以延长药物在胃内的滞留时间。采用溶剂蒸发技术制备微球，并对其粒径、形状、ζ电位、包封率和释放动力学进行表征。所制备的微球形状近似球形，包封率为86.34%，8小时后的漂浮率为61.06%。所制备的微球在胃内介质中呈现出药物的长效释放，因此可用于抗结核药物的持续递送。
