Department of Neurology, University of Toledo, Toledo, OH, USA.
Headache. 2011 Jun;51(6):869-79. doi: 10.1111/j.1526-4610.2011.01906.x.
Migraine and maltreatment are both common conditions that are more prevalent in women. Epidemiological evidence supports an association between childhood abuse and headache, as well as pain in general, although some controversy exists based on methodological concerns of studying the influence of remote, traumatic, stigmatizing events in an often depressed population. There is a growing scientific body of knowledge regarding the neurobiological effects of abuse on brain function and structure that suggest a possible role of early life stress in the pathogenesis of migraine, and a differential impact based on sex. Advances in our understanding of the basic mechanisms by which an adverse environment interacts with and changes the genome, may suggest new treatment strategies.
偏头痛和虐待都是常见的疾病，女性更为多发。流行病学证据支持儿童期虐待与头痛以及一般疼痛之间存在关联，尽管基于在通常抑郁人群中研究远程、创伤性、污名化事件影响的方法学问题，存在一些争议。越来越多的科学知识涉及虐待对大脑功能和结构的神经生物学影响，这表明早期生活压力可能在偏头痛的发病机制中起作用，并且基于性别的影响也不同。我们对不良环境与基因组相互作用并改变基因组的基本机制的理解的进步，可能会提出新的治疗策略。
