对-（4-脒基苯氧基）-苯甲醛-对-脒基苯腙二盐酸盐对金黄仓鼠杜氏利什曼原虫感染的作用
Action of p-(4-amidino-phenoxy)-benzaldehyde-p-amidino-phenylhydrazone dihydrochloride on Leishmania donovani infections in the golden hamster.
作者信息
Raether W, Seidenath H, Loewe H
出版信息
Ann Trop Med Parasitol. 1978 Dec;72(6):543-7. doi: 10.1080/00034983.1978.11719358.
The chemotherapeutic effect of a new diamidine, HOE 668, the p-(4-amidino-phenoxy)-benzaldehyde-p-amidino-phenylhydrazone dihydrochloride, was compared with that of known anti-leishmanial drugs in golden hamsters infected with Leishmania donovani. The effect of HOE 668 against visceral leishmaniasis proved superior to that of pentamidine isethionate and the pentavalent antimonial drugs, sodium stibogluconate and N-methylglucamine antimoniate. However, HOE 668 can be used only experimentally because of its toxicity. Its very good anti-leishmanial action qualifies HOE 668 as a standard compound in screening tests.
在感染杜氏利什曼原虫的金黄仓鼠中，将一种新型双脒化合物HOE 668（对-（4-脒基苯氧基）-苯甲醛对-脒基苯腙二盐酸盐）的化疗效果与已知抗利什曼原虫药物进行了比较。结果表明，HOE 668治疗内脏利什曼病的效果优于乙磺半胱氨酸戊烷脒以及五价锑化合物葡萄糖酸锑钠和甲基葡胺锑酸盐。然而，由于其毒性，HOE 668仅可用于实验。因其具有良好的抗利什曼原虫作用，HOE 668可作为筛选试验中的标准化合物。
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