Oosterhuis J W, Rammeloo R H, Cornelisse C J, De Jong B, Dam A, Sleijfer D T
Department of Pathology, University of Groningen, The Netherlands.
Hum Pathol. 1990 Jul;21(7):729-32. doi: 10.1016/0046-8177(90)90033-2.
The ploidy of 19 primary mediastinal malignant germ-cell tumors (GCT) was measured. Six tumors were (near) diploid. The median DNA index of the 13 remaining tumors was 1.91, indicating that most aneuploid tumors were near tetraploid. Seminomas and nonseminomatous GCTs were similar with respect to proportion of diploid tumors and median DNA index of the aneuploid tumors. The ploidy of mediastinal malignant GCTs is remarkably different from that of testicular GCTs of adults, but more similar to that of testicular GCTs of infancy. The pathogenesis of malignant mediastinal GCTs is probably different from that of testicular GCTs of adults, and more similar to the pathogenesis of infantile testicular GCTs. The difference in ploidy between mediastinal malignant GCTs and GCTs of the adult testis may help to differentiate between a primary extragonadal malignant GCT and a mediastinal metastasis from a primary testicular GCT.
对19例原发性纵隔恶性生殖细胞肿瘤（GCT）的倍性进行了测定。6例肿瘤为（近）二倍体。其余13例肿瘤的中位DNA指数为1.91，表明大多数非整倍体肿瘤接近四倍体。精原细胞瘤和非精原细胞瘤性GCT在二倍体肿瘤比例和非整倍体肿瘤的中位DNA指数方面相似。纵隔恶性GCT的倍性与成人睾丸GCT明显不同，但与婴儿睾丸GCT更相似。恶性纵隔GCT的发病机制可能与成人睾丸GCT不同，而与婴儿睾丸GCT的发病机制更相似。纵隔恶性GCT与成人睾丸GCT之间倍性的差异可能有助于鉴别原发性性腺外恶性GCT与原发性睾丸GCT的纵隔转移。
