Department of Biology, University of North Carolina at Charlotte, Charlotte, 28223 NC, United States.
World J Gastroenterol. 2011 May 28;17(20):2536-42. doi: 10.3748/wjg.v17.i20.2536.
microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of all human transcripts and are known regulators of various important cellular growth and differentiation factors. miRs have recently emerged as key regulatory molecules in chronic liver disease. This review details recent contributions to the field of miRs that influence liver development and the broad spectrum of disease, from non-alcoholic fatty liver disease to fibrosis/cirrhosis, with particular emphasis on hepatic stellate cells and potential use of miRs as therapeutic tools.
microRNAs (miRs) 是小的非编码 RNA，可调节靶基因的 mRNA 和蛋白质表达，从而导致 mRNA 稳定性或翻译抑制的改变。miRs 影响至少三分之一的人类转录物，是各种重要细胞生长和分化因子的已知调节剂。miRs 最近已成为慢性肝病的关键调节分子。本综述详细介绍了影响肝脏发育和广泛疾病的 miR 的最新研究进展，从非酒精性脂肪性肝病到纤维化/肝硬化，特别强调了肝星状细胞和 miR 作为治疗工具的潜在用途。
