Dannals R F, Ravert H T, Wilson A A, Wagner H N
Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205-2179.
Int J Rad Appl Instrum A. 1990;41(6):541-3. doi: 10.1016/0883-2889(90)90036-g.
Citalopram, a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described.
西酞普兰是一种选择性血清素再摄取抑制剂，用11C进行标记，以便利用正电子发射断层扫描对人脑中血清素摄取位点进行非侵入性体内研究。使用[11C]甲基碘作为前体，合成在约17分钟内完成。本文描述了合成、纯化、表征以及比活度的测定。
