Heart and Kidney Institute, College of Pharmacy, University of Houston, Houston, TX 77204, USA.
Curr Hypertens Rep. 2011 Aug;13(4):294-302. doi: 10.1007/s11906-011-0211-1.
The role of dopamine receptors in blood pressure regulation is well established. Genetic ablation of both dopamine D1-like receptor subtypes (D1, D5) and D2-like receptor subtypes (D2, D3, D4) results in a hypertensive phenotype in mice. This review focuses on the dopamine D1-like receptor subtypes D1 and D5 (especially D1 receptors), as they play a major role in regulating sodium homeostasis and blood pressure. Studies mostly describing the role of renal dopamine D1-like receptors are included, as the kidneys play a pivotal role in the maintenance of sodium homeostasis and the long-term regulation of blood pressure. We also attempt to describe the interaction between D1-like receptors and other proteins, especially angiotensin II type 1 and type 2 receptors, which are involved in the maintenance of sodium homeostasis and blood pressure. Finally, we discuss a new concept of renal D1 receptor regulation in hypertension that involves oxidative stress mechanisms.
多巴胺受体在血压调节中的作用已得到充分证实。在小鼠中，多巴胺 D1 样受体亚型（D1、D5）和 D2 样受体亚型（D2、D3、D4）的基因缺失会导致高血压表型。本综述重点介绍多巴胺 D1 样受体亚型 D1 和 D5（特别是 D1 受体），因为它们在调节钠稳态和血压方面发挥着重要作用。本文纳入了大多数描述肾多巴胺 D1 样受体作用的研究，因为肾脏在维持钠稳态和长期调节血压方面起着关键作用。我们还试图描述 D1 样受体与其他蛋白质（特别是参与维持钠稳态和血压的血管紧张素 II 型 1 和 2 受体）之间的相互作用。最后，我们讨论了高血压中肾 D1 受体调节的一个新概念，涉及氧化应激机制。
