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成人颞叶癫痫与神经外科治疗的可能性:磁共振成像的作用

[Temporal lobe epilepsy in adults and possibilities of neurosurgical treatment: the role of magnetic resonance].

作者信息

Malíková Hana, Liscák Roman, Vojtech Zdenek, Procházka Tomás, Marecková Iva, Dbalý Vladimír, Vymazal Josef, Kalina Miroslav, Vladyka Vilibald

机构信息

Radiodiagnostické oddelení Nemocnice Na Homolce, Praha. hana.malikova@homolka

出版信息

Cas Lek Cesk. 2011;150(4-5):254-9.

Abstract

Temporal lobe epilepsy is the most common type of focal epilepsy diagnosed in adult patients. According to the location of seizure generation it is classified as mesial temporal lobe epilepsy and neocortical lateral lobe epilepsy. Diagnosis of temporal lobe epilepsy can be proved by the combination of the clinical manifestation of partial complex seizures, scalp-video EEG monitoring, results of magnetic resonance imaging (MRI) and imaging of interictal fluoro-deoxy-glucose positron emission tomography. Mesial temporal sclerosis is the most common finding on MRI. Temporal lobe epilepsy is the most surgically amenable diagnosis and results of surgery treatments are clearly superior to the prolonged medical therapy; surgical treatment of the mesial temporal epilepsy with mesial temporal sclerosis has the best clinical results. Except for standard microsurgical approaches such as anterior temporal resection and selective amygdalo-hippocampectomy, stereotactic thermocoagulation amygdalo-hippocampectomy is provided in our epilepsy centre. This alternative approach has comparable clinical outcome to the standard surgery approaches in 2 years clinical follow-ups. MRI is important not only in diagnostic procedures, but also in neuronavigation of surgery approaches, per operation control of the extent of resections and postoperative follow-ups, especially in failed epilepsy surgery.

摘要

颞叶癫痫是成年患者中最常见的局灶性癫痫类型。根据癫痫发作起源部位,可分为内侧颞叶癫痫和新皮质外侧叶癫痫。颞叶癫痫的诊断可通过部分性复杂发作的临床表现、头皮视频脑电图监测、磁共振成像(MRI)结果以及发作间期氟脱氧葡萄糖正电子发射断层扫描成像来证实。内侧颞叶硬化是MRI上最常见的表现。颞叶癫痫是最适合手术治疗的诊断类型,手术治疗效果明显优于长期药物治疗;内侧颞叶硬化型内侧颞叶癫痫的手术治疗临床效果最佳。除了标准的显微手术方法,如前颞叶切除术和选择性杏仁核-海马切除术外,我们的癫痫中心还提供立体定向热凝杏仁核-海马切除术。在2年的临床随访中,这种替代方法与标准手术方法的临床结果相当。MRI不仅在诊断过程中很重要,而且在手术方法的神经导航、手术中切除范围的控制以及术后随访中也很重要,尤其是在癫痫手术失败的情况下。

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