Thomas-Schoemann Audrey, Alexandre Jérôme, Mongaret Céline, Azibi Sonia, Dauphin Alain, Goldwasser François, Lemare Francois
Hôpital Cochin, service de pharmacie, Paris, France.
Bull Cancer. 2011 Jun;98(6):645-53. doi: 10.1684/bdc.2011.1375.
Use of complementary and alternative medicine (CAM) has been reported to be more and more frequent among cancer patients in USA. The aim of this study was to analyze among French cancer patients the prevalence of CAM use, focusing on antioxidants (AO) that could interfere with antitumor agents. Seventy-nine patients, treated by antitumor chemotherapy in oncology day care unit, participated to an interview (medium age = 60 years old). CAM use was reported by 42% of patients: mostly AO (24%) (selenium, green tea and vitamins ACE, more specifically), but also relaxation, acupuncture, hypnosis (19%) and homeopathy (15%). Among patients using CAM, 66% of them indicated that their physicians were not aware of this use and 47% of them thought that CAM use was safe. Nevertheless, for seven patients who have taken AO, previous in vitro and preclinical studies suggested interactions with antitumor chemotherapy. Therefore, CAM use and, more specifically, AO use is common among cancer patients treated by antitumor chemotherapy in France. Nevertheless, AO could generate interactions with conventional treatment. Clinical studies are warranted to evaluate these interactions, and adequate communication with patients is needed.
据报道，在美国，补充和替代医学（CAM）在癌症患者中的使用越来越频繁。本研究的目的是分析法国癌症患者中CAM的使用情况，重点关注可能与抗肿瘤药物相互作用的抗氧化剂（AO）。79名在肿瘤日间护理单元接受抗肿瘤化疗的患者参与了访谈（平均年龄 = 60岁）。42%的患者报告使用了CAM：主要是AO（24%）（具体为硒、绿茶和维生素ACE），还有放松疗法、针灸、催眠（19%）和顺势疗法（15%）。在使用CAM的患者中，66%表示他们的医生不知道他们使用了CAM，47%认为使用CAM是安全的。然而，对于7名服用AO的患者，先前的体外和临床前研究表明AO与抗肿瘤化疗存在相互作用。因此，在法国接受抗肿瘤化疗的癌症患者中，CAM的使用，尤其是AO的使用很常见。然而，AO可能会与传统治疗产生相互作用。有必要进行临床研究以评估这些相互作用，并且需要与患者进行充分沟通。
