Institute of Environmental Science and Research Ltd, Porirua, New Zealand.
Tob Control. 2012 Jan;21(1):39-43. doi: 10.1136/tc.2010.040287. Epub 2011 Jun 2.
It has been suggested that inhibition of monoamine oxidase (MAO) activity by components of cigarette smoke may impact on smoking addiction, but it is unclear to what extent the known MAO inhibitors in tobacco smoke cause this inhibition.
MAO inhibitory activity was measured in a series of tobacco particulate matter preparations from different brands of cigarette and loose-leaf tobacco commonly available in New Zealand.
When tobacco extracts were diluted to contain a physiologically relevant nicotine concentration of 0.2 μM, all samples tested inhibited MAO-A and MAO-B by between 4% and 12% in a standard assay. Per mg of nicotine, samples from factory-made cigarettes contained significantly less MAO inhibitory activity than did samples from loose-leaf tobacco. When inhibitory activity was calculated on a per mg of tar basis, there was no significant difference between loose-leaf tobaccos and factory-made cigarettes.
The present study shows that the ratio of nicotine to MAO inhibitory activity varies depending on the type of tobacco product used. The roll-your-own tobaccos tested delivered more tar and more MAO inhibitory activity per mg of nicotine than the factory-made cigarettes. These findings suggest that smokers of roll-your-own tobacco may experience greater difficulty in stopping smoking.
香烟烟雾中的某些成分抑制单胺氧化酶（MAO）的活性，可能会影响吸烟成瘾，但香烟烟雾中已知的 MAO 抑制剂在多大程度上造成这种抑制作用尚不清楚。
在新西兰常见的不同品牌香烟和散装烟的一系列烟草颗粒物质制剂中测量 MAO 抑制活性。
当烟草提取物稀释至含有 0.2 μM 生理相关浓度的尼古丁时，所有测试样本在标准测定中均抑制 MAO-A 和 MAO-B 活性，抑制率在 4%至 12%之间。每毫克尼古丁，来自机制卷烟的样本所含 MAO 抑制活性显著低于来自散装烟的样本。当按每毫克焦油计算抑制活性时，散装烟和机制卷烟之间没有显著差异。
本研究表明，尼古丁与 MAO 抑制活性的比例取决于所使用的烟草制品类型。测试的自卷烟每毫克尼古丁释放的焦油和 MAO 抑制活性均高于机制卷烟。这些发现表明，自卷烟吸烟者可能更难以戒烟。
