Hanyu H, Yoneda Y, Katsunuma H, Miki T, Miwa T
Department of Geriatric Medicine, Tokyo Medical College.
Rinsho Shinkeigaku. 1990 Mar;30(3):324-6.
we report a patient with Wallenberg's syndrome caused by glioma of the lateral medulla oblongata, and review the literature for Wallenberg's syndrome associated with neoplastic disease. A 46-year-old man was admitted because of progressive dysphagia and vertigo. Neurological examination revealed atypical symptoms and signs of Wallenberg's syndrome on the right side, hypalgesia on the second and third divisions of the left trigeminal nerve, paresis of the right palate and uvula, and ataxia of the right extremities. Although CT showed no abnormality in the posterior fossa, MRI demonstrated a mass with abnormal signal intensities in the right dorsolateral portion of the medulla. Biopsy specimens showed astrocytoma (grade III). Based on the present case and a review of 10 previously reported cases of Wallenberg's syndrome caused by neoplastic disease, the clinical features of this syndrome are characterized by gradual development and steady progression of symptoms, non-classical or atypical symptomatology, numerous additional symptoms and signs depending on the site and size of tumors, and poor prognosis.
我们报告一例由延髓外侧胶质瘤引起的瓦伦贝格综合征患者，并回顾与肿瘤性疾病相关的瓦伦贝格综合征的文献。一名46岁男性因进行性吞咽困难和眩晕入院。神经系统检查发现右侧有非典型的瓦伦贝格综合征症状和体征，左侧三叉神经第二和第三分支感觉减退，右侧软腭和悬雍垂麻痹，以及右上肢共济失调。尽管CT显示后颅窝无异常，但MRI显示延髓右背外侧部分有一个信号强度异常的肿块。活检标本显示为星形细胞瘤（III级）。基于本病例以及对先前报道的10例由肿瘤性疾病引起的瓦伦贝格综合征病例的回顾，该综合征的临床特征为症状逐渐发展且进展稳定、非经典或非典型症状学、取决于肿瘤部位和大小的众多附加症状和体征以及预后不良。
