Canadian Center for Vaccinology, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S54-7. doi: 10.1016/j.ajog.2011.04.031. Epub 2011 Apr 24.
The purpose of this study was to determine whether maternal hospitalization for a respiratory-related condition during influenza season results in an increased risk of neonatal morbidity. With the use of a 13-year population-based cohort study of all singleton live births in Nova Scotia (1990-2002), neonatal outcomes were compared between women with and without hospital admission for respiratory illness during influenza season at any time in pregnancy. Logistic regression analyses were performed to examine infant outcomes and to estimate relative risks and 95% confidence intervals. Infants who were born to mothers who had been hospitalized for respiratory illness during influenza season at any time during pregnancy were more likely to be small for gestational age (15.3% vs 9.7%; adjusted relative risk, 1.66; 95% confidence interval, 1.11-2.49) and to have lower mean birthweight (3348.5 ± 498.2 g vs 3531.3 ± 504.1 g; β score, -86.67; P < .009) than were infants who were born to women without an influenza-season respiratory hospitalization during pregnancy. Our findings in a cohort of singleton infants who were born in a high-resource setting support the findings that were described in Bangladesh that demonstrated an increased number of small-for-gestational-age infants and a lower mean birthweight among babies who were born to mothers who were not protected by influenza vaccine.
本研究旨在确定母亲在流感季节因呼吸道相关疾病住院是否会增加新生儿发病的风险。本研究使用了一项针对新斯科舍省（1990-2002 年）所有单胎活产儿的 13 年基于人群的队列研究，比较了在妊娠任何时间因呼吸道疾病住院的孕妇所生新生儿与未住院孕妇的新生儿结局。采用 logistic 回归分析来评估婴儿结局，并估计相对风险和 95%置信区间。在妊娠任何时间因呼吸道疾病住院的母亲所生的婴儿，其小于胎龄儿的发生率更高（15.3%比 9.7%；调整后的相对风险为 1.66；95%置信区间为 1.11-2.49），且出生体重均值更低（3348.5 ± 498.2 g 比 3531.3 ± 504.1 g；β评分，-86.67；P <.009）。与妊娠期间未在流感季节因呼吸道疾病住院的孕妇所生婴儿相比，这一发现支持了在高资源环境下的单胎婴儿队列中得出的结论，即表明未接种流感疫苗的母亲所生的婴儿中，小胎龄儿的数量增加，且出生体重均值降低。
