Key Laboratory of Transplant Engineering and Immunology of Health Ministry of China, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan Province, PR China.
Cell Immunol. 2011;270(1):5-12. doi: 10.1016/j.cellimm.2011.05.006. Epub 2011 May 12.
Regulatory T cells (Tregs) are considered to be critical for the induction of transplant tolerance. Tregs counts were measured in blood, biopsy and urine sample after transplantation in many studies. Although not unanimous, some studies have suggested that Tregs is associated with better outcome and can also serve as an immune marker to predict the individual risk of rejection and identify tolerant patients. In this study, we systematically reviewed the correlation between Tregs and transplant outcomes, identifying if Tregs can predict transplant rejection and tolerance. A total of 22 articles were included and assessed, the results showed that Tregs in recipients are helpful to maintain a stable graft function, reduce acute/chronic rejection rate. And the Tregs in graft and urine, rather than in PBL, may have a better diagnostic value for transplant outcomes. However, since the low quality of included studies, results may be influenced by bias. More high quality studies with bigger sample size are still needed in future.
调节性 T 细胞（Tregs）被认为对诱导移植耐受至关重要。许多研究在移植后测量了血液、活检和尿液样本中的 Tregs 计数。虽然并非一致，但一些研究表明 Tregs 与更好的结果相关，也可以作为免疫标志物来预测个体排斥反应的风险并识别耐受患者。在这项研究中，我们系统地综述了 Tregs 与移植结果之间的相关性，确定 Tregs 是否可以预测移植排斥和耐受。共纳入并评估了 22 篇文章，结果表明，受体中的 Tregs 有助于维持移植物功能稳定，降低急性/慢性排斥率。而移植物和尿液中的 Tregs ，而不是 PBL 中的 Tregs ，可能对移植结果具有更好的诊断价值。然而，由于纳入研究的质量较低，结果可能受到偏倚的影响。未来仍需要更多高质量、大样本量的研究。
