The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
Cell Metab. 2011 Jun 8;13(6):621-6. doi: 10.1016/j.cmet.2011.05.004.
Sirtuins have emerged in recent years as critical regulators of metabolism, influencing numerous facets of energy and nutrient homeostasis. Here, we review recent advances on the role of this fascinating family of mammalian proteins and their well-orchestrated function in modulating mitochondrial activity.
近年来，Sirtuins 作为代谢的关键调节因子而备受关注，影响着能量和营养稳态的众多方面。在这里，我们回顾了近年来关于这个迷人的哺乳动物蛋白家族及其在调节线粒体活性方面的协调功能的研究进展。
