(E)-1-(β-D-吡喃半乳糖基)-4-(芳基)丁-3-烯-2-酮的合成与抗结核分枝杆菌活性筛选。
Synthesis and screening of (E)-1-(β-D-galactopyranosyl)-4-(aryl)but-3-ene-2-one against Mycobacterium tuberculosis.
机构信息
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab 160062, India.
出版信息
Bioorg Med Chem Lett. 2011 Jul 1;21(13):3947-50. doi: 10.1016/j.bmcl.2011.05.037. Epub 2011 May 15.
PMID:21641797
Abstract
A series of galactose-derived aryl enones were synthesised and screened against Mycobacterium tuberculosis H(37)Rv. Preliminary results were promising with MIC values in the range 1.56-12.5 μg/mL.
摘要
一系列半乳糖衍生的芳基烯酮被合成并对结核分枝杆菌 H(37)Rv 进行了筛选。初步结果令人鼓舞，MIC 值在 1.56-12.5μg/mL 范围内。
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