Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland.
Mol Oncol. 2011 Aug;5(4):308-14. doi: 10.1016/j.molonc.2011.05.002. Epub 2011 May 20.
Human cancers are characterized by the presence of genomic instability. Recently, two studies have catalogued the presence of a specific class of genomic aberrations, large deletions and insertions, in a few thousand human cancers and reported that most of the prevalent recurrent focal deletions targeted common fragile sites and large genes. In various experimental systems, deletions in common fragile sites and large genes have been linked to the presence of DNA replication stress. Thus, taken together, these results suggest the presence of DNA replication stress in human cancers, consistent with the recently proposed oncogene-induced DNA damage model for cancer development.
人类癌症的特征是存在基因组不稳定性。最近，有两项研究在几千例人类癌症中对一类特定的基因组异常（大片段缺失和插入）进行了编目，并报告说大多数常见的复发性局灶性缺失都靶向常见的脆性位点和大基因。在各种实验系统中，常见脆性位点和大基因的缺失与 DNA 复制应激的存在有关。因此，总的来说，这些结果表明人类癌症中存在 DNA 复制应激，与最近提出的癌基因诱导的 DNA 损伤模型一致，该模型是癌症发生的一种假说。
