Service d'Hématologie Oncologie Médicale, CHU du point G, BP 333 Bamako, Mali.
Clin Res Hepatol Gastroenterol. 2011 Oct;35(10):675-7. doi: 10.1016/j.clinre.2011.04.012. Epub 2011 Jun 8.
Gastrointestinal stromal tumors (GIST) usually showing a spindle cells pattern of cell proliferation have recently benefit from a molecular definition. Indeed imatinib mesylate (Gleevec(®)) treatment has dramatically improved the management of these tumors as they frequently express the c-kit oncogene. We report the first case of a metastatic gastric GIST in a man of 45 years diagnosed and treated in Mali. The gastric tumor was particularly aggressive with a large intra-abdominal and mesenteric spreading and liver metastases. The diagnosis was done on the CD117 and CD34 expression in the tumor sample obtained by laparotomy. After a 34 months 400mg/day imatinib mesylate (Gleevec(®)) treatment a dramatic tumor regression was obtained.
胃肠道间质肿瘤（GIST）通常表现为梭形细胞增殖模式，最近已从分子定义中受益。事实上，甲磺酸伊马替尼（格列卫（®））治疗极大地改善了这些肿瘤的治疗效果，因为它们经常表达 c-kit 致癌基因。我们报告了首例在马里诊断和治疗的 45 岁男性胃 GIST 转移病例。胃肿瘤具有侵袭性，腹腔内和肠系膜广泛扩散，并伴有肝转移。通过剖腹手术获得肿瘤样本，对 CD117 和 CD34 在肿瘤中的表达进行了诊断。在接受甲磺酸伊马替尼（格列卫（®））每天 400mg 治疗 34 个月后，肿瘤显著消退。
