[浸润性导管癌的分级、分期、DNA含量与预后]
[Grading, staging, DNA content and prognosis of invasive ductal breast cancer].
作者信息
Theissig F, Kunze K D, Haroske G, Meyer W, Dimmer V
机构信息
Institut für Pathologische Anatomie, Medizinischen Akademie, Carl Gustav Carus, Dresden.
出版信息
Zentralbl Chir. 1990;115(7):433-9.
The importance to prognostication of grading, staging, and image cytometric DNA parameters was investigated in 84 cases of invasive ductal mammary carcinoma. Correlations between tumour size, lymph node condition, and five-year survival were shown to be statistically significant. Similar correlations were found to exist between the grade of histopathological malignancy and various DNA parameters derived from the DNA histogram. However, the relevance of all the above single factors has proved to be of limited value in the individual tumour case. Multivariate analysis of DNA parameters, 80.3 percent in probability, was found to enable the best prognostic prediction of an individual course. These results suggested nuclear DNA content to be an objective marker of biological behaviour of a given tumour.
对84例浸润性导管乳腺癌患者，研究了分级、分期和图像细胞计量DNA参数对预后判断的重要性。结果显示，肿瘤大小、淋巴结状况与五年生存率之间的相关性具有统计学意义。组织病理学恶性程度分级与从DNA直方图得出的各种DNA参数之间也存在类似的相关性。然而，上述所有单一因素在个别肿瘤病例中的相关性已被证明价值有限。对DNA参数进行多变量分析发现，其在80.3%的概率上能够对个体病程做出最佳预后预测。这些结果表明，核DNA含量是特定肿瘤生物学行为的客观标志物。
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