钯介导的吡咯新合成：作为磷酸二酯酶 4 潜在抑制剂的评估。
Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4.
机构信息
Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500 049, India.
出版信息
Chem Commun (Camb). 2011 Jul 21;47(27):7779-81. doi: 10.1039/c1cc12321a. Epub 2011 Jun 3.
PMID:21643571
Abstract
A sequential Pd-mediated multi-component reaction followed by Suzuki or Heck or Sonogashira coupling in a single pot has been developed for the synthesis of functionalized pyrroles as potential inhibitors of PDE4.
摘要
已开发出一种 Pd 介导的顺序多组分反应，随后在单锅中进行 Suzuki、Heck 或 Sonogashira 偶联反应，用于合成作为 PDE4 潜在抑制剂的功能化吡咯。
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