喂食和禁食大鼠脂肪细胞中的磷酸肌醇代谢
Phosphoinositide metabolism in adipocytes from fed and fasted rats.
作者信息
Juhl H, Andersen P H, Richelsen B
机构信息
University Clinic of Endocrinology and Internal Medicine, Arhus Amtssygehus, Denmark.
出版信息
Biochem Int. 1990;20(6):1189-99.
Phosphoinositide turnover was investigated in adipocytes from fed and 48 hour fasted rats. Insulin stimulated phosphoinositide synthesis both in adipocytes from fed and fasted rats. Fasting enhanced this effect of insulin 2-fold. Hydrolysis of phosphoinositides to inositol phosphates was not activated by insulin, neither transient after 2 minutes nor after 60 minutes stimulation. Under similar conditions, alpha 1-adrenergic receptor stimulation induced a pronounced inositol phosphate production. Thus, it is suggested that phosphoinositide hydrolysis is not involved in insulin action. The alpha 1-adrenergic effect was similar in adipocytes from fed and fasting rats.
研究了喂食和禁食48小时大鼠脂肪细胞中磷酸肌醇的转换情况。胰岛素刺激喂食和禁食大鼠脂肪细胞中的磷酸肌醇合成。禁食使胰岛素的这种作用增强了两倍。胰岛素对磷酸肌醇水解为肌醇磷酸没有激活作用，无论是刺激2分钟后的短暂作用还是刺激60分钟后的作用均未激活。在相似条件下，α1-肾上腺素能受体刺激可诱导明显的肌醇磷酸生成。因此，提示磷酸肌醇水解不参与胰岛素作用。喂食和禁食大鼠脂肪细胞中的α1-肾上腺素能效应相似。
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