Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California 91010, USA.
J Org Chem. 2011 Aug 5;76(15):6169-76. doi: 10.1021/jo200899v. Epub 2011 Jun 28.
The asymmetric synthesis of the core structure of leucosceptroids A-D has been achieved. The key steps of the synthesis includes the formation of the cis-2,5-disubstituted THF ring by TPAP catalytic oxidative cyclization followed by a highly diastereoselective intramolecular Diels-Alder reaction to fashion the fused tricyclic hydrindane ring system.
已实现了 leucosceptroids A-D 核心结构的不对称合成。合成的关键步骤包括通过 TPAP 催化氧化环化形成顺式-2,5-二取代四氢呋喃环，然后通过高度非对映选择性的分子内 Diels-Alder 反应形成稠合三环茚烷环系统。
